They have forty-five minutes to save the world. They need forty-six.
The story of how a mysterious suitcase brings together, and changes, the lives of a divorced dad, an unhappy housewife, two hitmen, a pair of street thugs, two love struck teens, two FBI men and a psychedelic toad. Based on Pulitzer Prize-winning humorist Dave Barry's best-selling first novel, "Big Trouble."
Tim Allen Eliot Arnold
Rene Russo Anna Herk
Ben Foster Matt Arnold
Jason Lee Puggy
Stanley Tucci Arthur Herk
Dennis Farina Henry Desalvo
Zooey Deschanel Jenny Herk
Janeane Garofalo Monica Romero
Sofía Vergara Nina
Tom Sizemore Snake
Johnny Knoxville Eddie
Omar Epps Seitz
Heavy D Greer
Patrick Warburton Walter Kramitz
Jack Kehler Leonard
DJ Qualls Andrew
Michael McShane Bruce
Andy Richter Jack/Ralph Pendick
Daniel London John
Lars Arentz-Hansen Leo
Cullen Douglas Captain Justin Hobart
Flip Schultz Co-Pilot Jan Vigushin
Patrick Mickler Cigar Buddy
Gerald Owens Cigar Buddy
Mitchell Carrey Cigar Buddy
Nathalie Latronico Heather Weintraub
Jon Kasdan Jack Pendick Trainee
Ian Marioles Editorial Assistant
Philip Nolen Deeber
David Koepp Annoyed Sports Radio Host (voice)
Barry Sonnenfeld Confused Sports Radio Call In (voice)
Jay Rasumny Courier #1
Ruben Gomez Courier #2
Antoni Corone William Spaulding
Siobhan Fallon Hogan Fly by Air Ticket Agent
Kava Stewartson Sour Airport Security
Gloria Laino Airport X-Ray Operator
Carmen López Airport Stern Security Woman
Mark Salem Fly By Air Baggage Handler
Renato Campilongo Gang Leader
Marc Macaulay Arch Ridley
James Martin Kelly Geo Salesman
Dave Corey Cellmate Dwight
Selma Cipes Retiree #1
Sid Raymond Retiree #2
Jody Wilson Retiree #3
Maurice Alvey Retiree #4
Mia Finnegan Aerobics Announcer (voice)
Eric Geller Aerobics Announcer (voice)
Paul Barth Airline Pilot
Martha Stewart Herself
Deborah Smith Ford Bag Lady (uncredited)
Ron Madoff Extra
- Tim AllenEliot Arnold
- Rene RussoAnna Herk
- Ben FosterMatt Arnold
- Jason LeePuggy
- Stanley TucciArthur Herk
- Dennis FarinaHenry Desalvo
- Zooey DeschanelJenny Herk
- Janeane GarofaloMonica Romero
- Sofía VergaraNina
- Tom SizemoreSnake
- Johnny KnoxvilleEddie
- Omar EppsSeitz
- Heavy DGreer
- Patrick WarburtonWalter Kramitz
- Jack KehlerLeonard
- DJ QuallsAndrew
- Michael McShaneBruce
- Andy RichterJack/Ralph Pendick
- Daniel LondonJohn
- Lars Arentz-HansenLeo
- Cullen DouglasCaptain Justin Hobart
- Flip SchultzCo-Pilot Jan Vigushin
- Patrick MicklerCigar Buddy
- Gerald OwensCigar Buddy
- Mitchell CarreyCigar Buddy
- Nathalie LatronicoHeather Weintraub
- Jon KasdanJack Pendick Trainee
- Ian MariolesEditorial Assistant
- Philip NolenDeeber
- David KoeppAnnoyed Sports Radio Host (voice)
- Barry SonnenfeldConfused Sports Radio Call In (voice)
- Jay RasumnyCourier #1
- Ruben GomezCourier #2
- Antoni CoroneWilliam Spaulding
- Siobhan Fallon HoganFly by Air Ticket Agent
- Kava StewartsonSour Airport Security
- Gloria LainoAirport X-Ray Operator
- Carmen LópezAirport Stern Security Woman
- Mark SalemFly By Air Baggage Handler
- Renato CampilongoGang Leader
- Marc MacaulayArch Ridley
- James Martin KellyGeo Salesman
- Dave CoreyCellmate Dwight
- Selma CipesRetiree #1
- Sid RaymondRetiree #2
- Jody WilsonRetiree #3
- Maurice AlveyRetiree #4
- Mia FinneganAerobics Announcer (voice)
- Eric GellerAerobics Announcer (voice)
- Paul BarthAirline Pilot
- Martha StewartHerself
- Deborah Smith FordBag Lady (uncredited)
- Ron MadoffExtra